CSTL

HoldHot Air

Castle Biosciences, Inc. · Healthcare · United States · $1.0B cap · $13.1M/day traded

$36.68 +6.3% · close 28 Oct · scored 29 Oct

StockRank up 1.9 since 28 Oct.

Hot Air: Rising on momentum alone: weak business, rich price.

55
StockRank
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Quality
48
Value
33
Momentum
68

As of 29 Oct 2026, MoatMap's StockRank for Castle Biosciences, Inc. (CSTL) is 55/100, ranked against 24,000+ stocks in 35 markets (Quality 48, Value 33, Momentum 68, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-4.2%
peers -30.5%
D/E
0.1x
peers 0.2x
Dividend %
—
trailing yield

ABOUT CASTLE BIOSCIENCES, INC.

Read

Castle Biosciences, Inc. is a commercial-stage dermatological diagnostics company focused on improving patient care through its proprietary genomic tests for skin cancers. The company's tests provide actionable information to clinicians and patients to guide treatment decisions and predict recurrence risk for melanoma, cutaneous squamous cell carcinoma, and other dermatologic conditions. Castle Biosciences holds a niche leadership position by developing and commercializing clinically validated molecular diagnostics for challenging dermatologic cancers.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue137.0M219.8M332.1M344.2M35.9%357.3M373.5M412.4M9.5%
EPS-2.58-2.140.66-0.83—-0.64-1.26-0.91—
Shares26.6M27.4M28.5M29.7M+11.8%30.5M———
Debt13.4M15.3M26.3M36.9M40.2%36.6M———
Equity399.1M391.3M455.8M470.9M5.7%————
Op CF-41.7M-5.6M64.9M64.3M-0.8%42.6M———
Inv CF-166.5M-16.2M-50.1M-60.4M—————
Fin CF1.5M-2.3M6.1M-7.0M—————
Loading 1Y...
PRICE (1Y) · USD-0.3%
32.033.234.435.636.817 Sep8 Oct28 Oct
SMA 50SMA 200

Price checkFinding a floorExperimental

No new 52-week low for 23 weeks, 107% above that low, but not back above a rising 50-day average.

The Momentum score still reads 68: it looks back six months, so it has not caught up with this fall.

SwingsVery bumpy

Swung more than 72% of stocks we rank over the past year (57% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$36.68
RSI (14)
61.8
52-Week Range-17.2% from high
Low $17.72High $44.28

SCORE BREAKDOWN

Quality
48
ROIC
-3.7%40.3
ROE
-4.2%39.5
GP/Assets
47.7%86.1
Op. Margin
-3.0%31.2
FCF/Assets
-0.1%44.8
Piotroski
316.0
Int. Cover
-50.0x5.8
D/E Ratio
0.08x65.8
Current Ratio
6.04x77.7
Value
33
P/E (TTM)
—N/A
EV/EBITDA
-47.3x25.0
P/FCF
—N/A
P/B
2.1x55.1
P/S
2.8x56.4
Div Yield
—N/A
Momentum
68
52W High %
83%74.4
RS 6M
43%88.6
SMA 50/200
1.19x88.3
EPS Rev 4W
+7.6%95.7
EPS Rev 12W
+4.5%77.1
EPS Improve
-43%9.8
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$1.0B
P/E (Forward)
-36.2x
Gross Margin
77.3%

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of CSTL are excluded.

TickerCompanyMkt CapStockRankSignal
CSTLCastle Biosciences, Inc.(you)$1.0B55Hold
NEONeoGenomics, Inc.$2.1B49Hold
MYGNMyriad Genetics, Inc.$557M46Hold
FLGTFulgent Genetics, Inc.$553M46Hold
OPKOPKO Health, Inc.$1.2B37Hold
WGSGeneDx Holdings Corp.$1.7B35Hold
CDNACareDx, Inc.$3.6B62Hold
BLLNBillionToOne, Inc.$5.1B57Hold
ADPTAdaptive Biotechnologies Corporation$4.1B47Hold
GRALGRAIL, Inc.$5.9B50Hold

Peer medians: ROE -30.5% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

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Castle Biosciences, Inc. (CSTL): Stock Score Summary

Castle Biosciences, Inc. (CSTL) has a MoatMap StockRank of 55/100 based on Quality (48/100), Value (33/100), and Momentum (68/100) factor scores. The current signal is HOLD.

Castle Biosciences, Inc. is a commercial-stage dermatological diagnostics company focused on improving patient care through its proprietary genomic tests for skin cancers. The company's tests provide actionable information to clinicians and patients to guide treatment decisions and predict recurrence risk for melanoma, cutaneous squamous cell carcinoma, and other dermatologic conditions. Castle Biosciences holds a niche leadership position by developing and commercializing clinically validated molecular diagnostics for challenging dermatologic cancers.

Key Financial Metrics

Price$36.68
Market Cap$1.0B
P/E (Forward)-36.22
Price/Book2.15
Return on Equity-4.2%
Return on Invested Capital-3.7%
Debt/Equity0.08x
Gross Margin77.3%
Operating Margin-3.0%
Revenue Growth20.1%
Free Cash Flow$-489K

Castle Biosciences, Inc. operates in the Diagnostics & Research industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Castle Biosciences, Inc.’s (CSTL) StockRank?
MoatMap’s StockRank for Castle Biosciences, Inc. (CSTL) is 55/100, with a Hold signal. It is a composite of Quality (48), Value (33), and Momentum (68), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Castle Biosciences, Inc. have an economic moat?
Castle Biosciences, Inc. (CSTL) has a Quality factor score of 48/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Castle Biosciences, Inc. a buy, hold, or sell?
MoatMap’s current signal for Castle Biosciences, Inc. (CSTL) is Hold, based on a StockRank of 55/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Castle Biosciences, Inc. in?
Castle Biosciences, Inc. (CSTL) operates in the Healthcare sector, specifically the Diagnostics & Research industry (United States).