IOVA

HoldHot Air

Iovance Biotherapeutics, Inc. · Healthcare · United States · $6.4B cap · $221.7M/day traded

$13.78 -2.2% · close 26 Oct · scored 24 Oct

Hot Air: Rising on momentum alone: weak business, rich price.

43
StockRank
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Quality
29
Value
22
Momentum
84

As of 24 Oct 2026, MoatMap's StockRank for Iovance Biotherapeutics, Inc. (IOVA) is 43/100, ranked against 24,000+ stocks in 35 markets (Quality 29, Value 22, Momentum 84, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.3x
ROE
-40.4%
peers -30.9%
D/E
0.1x
peers 0.2x
Dividend %
—
trailing yield

ABOUT IOVANCE BIOTHERAPEUTICS, INC.

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Iovance Biotherapeutics, Inc. is a pioneer in the development of tumor-infiltrating lymphocyte (TIL) therapies for patients with solid tumor cancers. The company's competitive moat is its first-mover advantage, proprietary manufacturing processes, and FDA approval for Amtagvi, the first cellular therapy for a solid tumor. It operates as a leading-edge biotechnology player in the oncology space.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue01.2M164.1M263.5M1388.7%325.0M412.7M593.6M50.1%
EPS-1.05-1.89-1.28-1.09—-0.69-0.45-0.20—
Shares446.5M256.1M305.3M411.9M-7.7%453.0M———
Debt85.4M75.9M58.3M49.4M-16.7%46.0M———
Equity499.6M584.6M710.4M698.6M11.8%————
Op CF-292.8M-361.8M-353.0M-302.4M—-264.2M———
Inv CF256.5M-155.2M-96.4M47.5M—————
Fin CF190.2M463.0M390.7M300.8M—————
Loading 1Y...
PRICE (1Y) · USD+47.2%
9.410.712.113.514.915 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkIn an uptrendExperimental

Above its 200-day average and 8% below its 52-week high.

SwingsVery bumpy

Swung more than 96% of stocks we rank over the past year (105% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$13.78
RSI (14)
56.7
52-Week Range-10.3% from high
Low $1.76High $15.37

SCORE BREAKDOWN

Quality
29
ROIC
-38.2%19.6
ROE
-40.4%20.8
GP/Assets
17.2%39.8
Op. Margin
-52.3%20.1
FCF/Assets
-32.5%13.3
Piotroski
25.8
Int. Cover
—N/A
D/E Ratio
0.06x69.0
Current Ratio
4.34x68.8
Value
22
P/E (TTM)
—N/A
EV/EBITDA
-23.6x25.0
P/FCF
—N/A
P/B
8.7x13.4
P/S
19.6x14.9
Div Yield
—N/A
Momentum
84
52W High %
90%88.3
RS 6M
295%99.9
SMA 50/200
1.96x99.8
EPS Rev 4W
+27.9%99.1
EPS Rev 12W
+39.1%95.9
EPS Improve
+72%65.5
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$6.4B
P/E (Forward)
-72.0x
Gross Margin
48.4%

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of IOVA are excluded.

TickerCompanyMkt CapStockRankSignal
IOVAIovance Biotherapeutics, Inc.(you)$6.4B43Hold
TWSTTwist Bioscience Corporation$9.3B43Hold
TGTXTG Therapeutics, Inc.$8.3B48Hold
BLTEBelite Bio, Inc$5.9B33Sell
TVTXTravere Therapeutics, Inc.$4.7B35Sell
TARSTarsus Pharmaceuticals, Inc.$3.2B47Hold
RYTMRhythm Pharmaceuticals, Inc.$6.1B25Sell
ARQTArcutis Biotherapeutics, Inc.$3.9B53Hold
PTCTPTC Therapeutics, Inc.$5.1B27Sell
ORKAOruka Therapeutics, Inc.$5.3B25Sell

Peer medians: ROE -30.9% · P/E 27.3x · Gross margin 63.3%

Company Deep Dive

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Iovance Biotherapeutics, Inc. (IOVA): Stock Score Summary

Iovance Biotherapeutics, Inc. (IOVA) has a MoatMap StockRank of 43/100 based on Quality (29/100), Value (22/100), and Momentum (84/100) factor scores. The current signal is HOLD.

Iovance Biotherapeutics, Inc. is a pioneer in the development of tumor-infiltrating lymphocyte (TIL) therapies for patients with solid tumor cancers. The company's competitive moat is its first-mover advantage, proprietary manufacturing processes, and FDA approval for Amtagvi, the first cellular therapy for a solid tumor. It operates as a leading-edge biotechnology player in the oncology space.

Key Financial Metrics

Price$13.78
Market Cap$6.4B
P/E (Forward)-71.98
Price/Book8.67
Return on Equity-40.4%
Return on Invested Capital-38.2%
Debt/Equity0.06x
Gross Margin48.4%
Operating Margin-52.3%
Revenue Growth65.7%
Free Cash Flow$-296M

Iovance Biotherapeutics, Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Iovance Biotherapeutics, Inc.’s (IOVA) StockRank?
MoatMap’s StockRank for Iovance Biotherapeutics, Inc. (IOVA) is 43/100, with a Hold signal. It is a composite of Quality (29), Value (22), and Momentum (84), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Iovance Biotherapeutics, Inc. have an economic moat?
Iovance Biotherapeutics, Inc. (IOVA) has a Quality factor score of 29/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Iovance Biotherapeutics, Inc. a buy, hold, or sell?
MoatMap’s current signal for Iovance Biotherapeutics, Inc. (IOVA) is Hold, based on a StockRank of 43/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Iovance Biotherapeutics, Inc. in?
Iovance Biotherapeutics, Inc. (IOVA) operates in the Healthcare sector, specifically the Biotechnology industry (United States).