MNPR

SellHot Air

Monopar Therapeutics Inc. · Healthcare · United States · $474M cap · $10.7M/day traded

$70.54 -0.2% · close 26 Oct · scored 27 Oct

Hot Air: Rising on momentum alone: weak business, rich price.

34
StockRank
Get score and insider alerts
Quality
40
Value
27
Momentum
56

As of 27 Oct 2026, MoatMap's StockRank for Monopar Therapeutics Inc. (MNPR) is 34/100, ranked against 24,000+ stocks in 35 markets (Quality 40, Value 27, Momentum 56, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-19.5%
peers -30.5%
D/E
0.0x
peers 0.2x
Dividend %
—
trailing yield

ABOUT MONOPAR THERAPEUTICS INC.

Read

Monopar Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on developing innovative treatments for severe cancers. Its proprietary drug candidates target mechanisms that address chemotherapy-induced toxicities and resistance, alongside novel anti-cancer agents. Monopar operates as a niche player in oncology, aiming to improve outcomes for patients with difficult-to-treat cancers and significant unmet medical needs.

FINANCIAL SUMMARY (USD)

Year20212022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue00000———28.3M—
EPS-3.65-1.60-1.35-4.11-1.85—-2.20-3.04-1.92—
Shares2.5M6.7M6.7M6.1M6.7M+165.6%6.7M———
Debt08.4K000.2M164.1%0.2M———
Equity18.9M10.1M5.6M55.0M137.8M64.2%————
Op CF-7.3M-7.2M-7.9M-6.4M-12.2M—-12.2M———
Inv CF0-4.9M4.9M-14.3M-63.5M—————
Fin CF10.9M32.9K2.0M59.3M91.6M—————
Loading 1Y...
PRICE (1Y) · USD-32.4%
69.378.086.895.610415 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkNo clear trendExperimental

No clear trend: not near its 52-week low, and not in a steady uptrend.

SwingsVery bumpy

Swung more than 77% of stocks we rank over the past year (63% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$70.54
RSI (14)
35.1
52-Week Range-43.5% from high
Low $50.07High $124.82

SCORE BREAKDOWN

Quality
40
ROIC
-13.6%32.0
ROE
-19.5%29.8
GP/Assets
—N/A
Op. Margin
0.0%38.6
FCF/Assets
-4.3%37.3
Piotroski
321.4
Int. Cover
—N/A
D/E Ratio
0.00x93.0
Current Ratio
33.56x98.4
Value
27
P/E (TTM)
—N/A
EV/EBITDA
—N/A
P/FCF
—N/A
P/B
3.6x35.4
P/S
—N/A
Div Yield
—N/A
Momentum
56
52W High %
57%35.3
RS 6M
24%82.3
SMA 50/200
1.23x90.6
EPS Rev 4W
0.0%51.1
EPS Rev 12W
+38.9%95.4
EPS Improve
+13%29.3
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$474M
P/E (Forward)
-36.9x
Gross Margin
—

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of MNPR are excluded.

TickerCompanyMkt CapStockRankSignal
MNPRMonopar Therapeutics Inc.(you)$474M34Sell
DMACDiaMedica Therapeutics Inc.$470M31Sell
ARVNArvinas, Inc.$471M40Hold
GYREGyre Therapeutics, Inc.$620M38Hold
RZLTRezolute, Inc.$373M29Sell
PRTC.LPureTech Health plc$361M30Sell
SGMTSagimet Biosciences Inc.$679M37Hold
OVIDOvid Therapeutics Inc.$422M25Sell
CCCCC4 Therapeutics, Inc.$376M27Sell
ASMBAssembly Biosciences, Inc.$404M25Sell

Peer medians: ROE -30.5% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

Request Deep Dive(50 Feathers)

Monopar Therapeutics Inc. (MNPR): Stock Score Summary

Monopar Therapeutics Inc. (MNPR) has a MoatMap StockRank of 34/100 based on Quality (40/100), Value (27/100), and Momentum (56/100) factor scores. The current signal is SELL.

Monopar Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on developing innovative treatments for severe cancers. Its proprietary drug candidates target mechanisms that address chemotherapy-induced toxicities and resistance, alongside novel anti-cancer agents. Monopar operates as a niche player in oncology, aiming to improve outcomes for patients with difficult-to-treat cancers and significant unmet medical needs.

Key Financial Metrics

Price$70.54
Market Cap$474M
P/E (Forward)-36.88
Price/Book3.62
Return on Equity-19.5%
Return on Invested Capital-13.6%
Debt/Equity0.00x
Operating Margin0.0%
Free Cash Flow$-6M

Monopar Therapeutics Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Monopar Therapeutics Inc.’s (MNPR) StockRank?
MoatMap’s StockRank for Monopar Therapeutics Inc. (MNPR) is 34/100, with a Sell signal. It is a composite of Quality (40), Value (27), and Momentum (56), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Monopar Therapeutics Inc. have an economic moat?
Monopar Therapeutics Inc. (MNPR) has a Quality factor score of 40/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Monopar Therapeutics Inc. a buy, hold, or sell?
MoatMap’s current signal for Monopar Therapeutics Inc. (MNPR) is Sell, based on a StockRank of 34/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Monopar Therapeutics Inc. in?
Monopar Therapeutics Inc. (MNPR) operates in the Healthcare sector, specifically the Biotechnology industry (United States).