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SYRE

SellHot Air

Spyre Therapeutics, Inc. · Healthcare · United States · $8.0B · Avg Vol: $89M/d

23
StockRank
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Q
33
V
24
M
53
P/E (TTM)
ROE
-23.0%
D/E
0.0x
Dividend %

COMPANY DESCRIPTION

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing next-generation therapeutics for inflammatory bowel disease (IBD). The company utilizes advanced biologics engineering to create antibody candidates with superior efficacy and extended half-lives. Spyre's competitive position is built on its rational combination therapies and a pipeline designed to challenge established biologics in the immunology market.

FINANCIAL SUMMARY (USD)

Year20212022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue2.3M0.9M00-62.0%
EPS-0.75-5.71-3.18-1.98-1.92-2.88-3.52
Shares86.8M86.8M60.3M78.2M-10.0%88.2M
Debt5.1M4.6M0-8.5%
Equity50.3M184.0M517.8M715.2M142.3%
Op CF-80.1M-99.9M-157.4M-169.3M-208.9M
Inv CF57.0M-108.4M-353.3M-143.5M
Fin CF42.7M361.1M410.9M309.0M
Loading 1Y...
PRICE (1Y)-8.9%
87.0592.5297.99103109Jul 29Aug 19Sep 9
SMA 50SMA 200

Close
$89.14
RSI (14)
15.9
52W High
$110.18
From 52W High
0.8%

SCORE BREAKDOWN

Quality
33
ROIC
-37.7%20.4
ROE
-23.0%29.0
GP/Assets
-27.7%3.4
Op. Margin
0.0%38.1
FCF/Assets
-11.4%28.0
Piotroski
211.9
Int. Cover
N/A
D/E Ratio
0.00x98.0
Current Ratio
18.53x95.3
Value
24
P/E (TTM)
N/A
EV/EBITDA
N/A
P/FCF
N/A
P/B
8.2x15.3
P/S
N/A
Div Yield
N/A
Momentum
53
52W High %
81%68.8
RS 6M
101%96.9
SMA 50/200
1.57x98.8
EPS Rev 4W
-9.8%9.1
EPS Rev 12W
-13.3%10.1
EPS Improve
-79%6.8
Q Growth
N/A

FUNDAMENTALS

Market Cap
$8.0B
P/E (Forward)
-25.9x
Gross Margin

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of SYRE are excluded.

TickerCompanyMkt CapStockRankSignal
SYRESpyre Therapeutics, Inc.(you)$8.0B23Sell
IBRXImmunityBio, Inc.$8.5B22Sell
IMVTImmunovant, Inc.$8.5B21Sell
CRNXCrinetics Pharmaceuticals, Inc.$9.0B24Sell
CYTKCytokinetics, Incorporated$10.0B22Sell
KYMRKymera Therapeutics, Inc.$9.7B21Sell
DNTHDianthus Therapeutics, Inc.$5.9B23Sell
PCVXVaxcyte, Inc.$8.9B28Sell
SRRKScholar Rock Holding Corporation$7.0B19Strong Sell
AXSMAxsome Therapeutics, Inc.$10.4B25Sell

Peer medians: ROE -30.8% · P/E 27.0x · Gross margin 58.3%

Spyre Therapeutics, Inc. (SYRE): Stock Score Summary

Spyre Therapeutics, Inc. (SYRE) has a MoatMap StockRank of 23/100 based on Quality (33/100), Value (24/100), and Momentum (53/100) factor scores. The current signal is SELL.

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing next-generation therapeutics for inflammatory bowel disease (IBD). The company utilizes advanced biologics engineering to create antibody candidates with superior efficacy and extended half-lives. Spyre's competitive position is built on its rational combination therapies and a pipeline designed to challenge established biologics in the immunology market.

Key Financial Metrics

Price$89.14
Market Cap$8.0B
P/E (Forward)-25.91
Price/Book8.21
Return on Equity-23.0%
Return on Invested Capital-37.7%
Debt/Equity0.00x
Operating Margin0.0%
Free Cash Flow$-89M

Spyre Therapeutics, Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Spyre Therapeutics, Inc.’s (SYRE) StockRank?
MoatMap’s StockRank for Spyre Therapeutics, Inc. (SYRE) is 23/100, with a Sell signal. It is a composite of Quality (33), Value (24), and Momentum (53) factor ranks across MoatMap’s universe of 25,000+ stocks.
Does Spyre Therapeutics, Inc. have an economic moat?
Spyre Therapeutics, Inc. (SYRE) has a Quality factor score of 33/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Spyre Therapeutics, Inc. a buy, hold, or sell?
MoatMap’s current signal for Spyre Therapeutics, Inc. (SYRE) is Sell, based on a StockRank of 23/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Spyre Therapeutics, Inc. in?
Spyre Therapeutics, Inc. (SYRE) operates in the Healthcare sector, specifically the Biotechnology industry (United States).