TSHA

Strong SellSinker

Taysha Gene Therapies, Inc. · Healthcare · United States · $1.3B cap · $18.7M/day traded

$4.01 +1.3% · close 26 Oct · scored 27 Oct

Sinker: Weak, expensive and falling. Nothing here to keep it afloat.

8
StockRank
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Quality
26
Value
25
Momentum
27

As of 27 Oct 2026, MoatMap's StockRank for Taysha Gene Therapies, Inc. (TSHA) is 8/100, ranked against 24,000+ stocks in 35 markets (Quality 26, Value 25, Momentum 27, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-47.1%
peers -30.1%
D/E
0.1x
peers 0.2x
Dividend %
—
trailing yield

ABOUT TAYSHA GENE THERAPIES, INC.

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Taysha Gene Therapies, Inc. is a clinical-stage gene therapy company focused on developing therapies for monogenic central nervous system (CNS) diseases. The company utilizes a robust adeno-associated virus (AAV) gene therapy platform to address a range of neurological disorders with high unmet medical needs. Taysha operates as a specialized player in the burgeoning gene therapy sector, aiming to deliver potentially curative treatments for severe inherited brain disorders.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue2.5M15.5M8.3M9.8M57.5%5.5M1.8M19.7M41.8%
EPS-0.83-0.96-0.36-0.34—-0.41-0.47-0.46—
Shares287.4M187.0M204.9M285.1M-0.8%325.8M———
Debt59.9M61.1M63.2M70.1M5.4%56.7M———
Equity0.9M74.9M71.5M246.9M538.4%————
Op CF-88.4M-73.0M-81.2M-93.1M—-132.2M———
Inv CF-24.9M-7.4M-0.4M-0.6M—————
Fin CF52.1M136.4M76.7M274.6M—————
Loading 1Y...
PRICE (1Y) · USD-20.8%
3.53.94.34.75.215 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkStill fallingExperimental

Made a new 52-week low 8 trading days ago, 45% below its 52-week high. The fall has not stopped yet.

SwingsVery bumpy

Swung more than 84% of stocks we rank over the past year (72% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$4.01
RSI (14)
41.0
52-Week Range-45.1% from high
Low $3.45High $7.30

SCORE BREAKDOWN

Quality
26
ROIC
-47.2%16.6
ROE
-47.1%18.9
GP/Assets
1.6%14.0
Op. Margin
-2792.3%4.7
FCF/Assets
-27.3%16.8
Piotroski
438.6
Int. Cover
-50.0x5.8
D/E Ratio
0.15x56.5
Current Ratio
17.77x94.6
Value
25
P/E (TTM)
—N/A
EV/EBITDA
-5.9x25.0
P/FCF
—N/A
P/B
3.3x38.3
P/S
235.2x4.3
Div Yield
—N/A
Momentum
27
52W High %
55%32.9
RS 6M
-45%14.0
SMA 50/200
0.93x39.7
EPS Rev 4W
0.0%51.1
EPS Rev 12W
-6.3%16.9
EPS Improve
-13%16.5
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$1.3B
P/E (Forward)
-8.6x
Gross Margin
100.0%

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of TSHA are excluded.

TickerCompanyMkt CapStockRankSignal
TSHATaysha Gene Therapies, Inc.(you)$1.3B8Strong Sell
OCULOcular Therapeutix, Inc.$1.4B7Strong Sell
AVLNAvalyn Pharma Inc.$1.2B7Strong Sell
INBXInhibrx Biosciences, Inc.$1.4B5Strong Sell
GENBGenerate Biomedicines, Inc.$1.6B8Strong Sell
DMRADamora Therapeutics, Inc.$1.3B12Strong Sell
CTYCity Therapeutics, Inc.$1.0B6Strong Sell
RAPPRapport Therapeutics, Inc.$1.2B12Strong Sell
LYCALycia Therapeutics, Inc.$1.6B10Strong Sell
STOKStoke Therapeutics, Inc.$1.6B9Strong Sell

Peer medians: ROE -30.1% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

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Taysha Gene Therapies, Inc. (TSHA): Stock Score Summary

Taysha Gene Therapies, Inc. (TSHA) has a MoatMap StockRank of 8/100 based on Quality (26/100), Value (25/100), and Momentum (27/100) factor scores. The current signal is STRONG SELL.

Taysha Gene Therapies, Inc. is a clinical-stage gene therapy company focused on developing therapies for monogenic central nervous system (CNS) diseases. The company utilizes a robust adeno-associated virus (AAV) gene therapy platform to address a range of neurological disorders with high unmet medical needs. Taysha operates as a specialized player in the burgeoning gene therapy sector, aiming to deliver potentially curative treatments for severe inherited brain disorders.

Key Financial Metrics

Price$4.01
Market Cap$1.3B
P/E (Forward)-8.56
Price/Book3.33
Return on Equity-47.1%
Return on Invested Capital-47.2%
Debt/Equity0.15x
Gross Margin100.0%
Operating Margin-2792.3%
Free Cash Flow$-94M

Taysha Gene Therapies, Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Taysha Gene Therapies, Inc.’s (TSHA) StockRank?
MoatMap’s StockRank for Taysha Gene Therapies, Inc. (TSHA) is 8/100, with a Strong Sell signal. It is a composite of Quality (26), Value (25), and Momentum (27), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Taysha Gene Therapies, Inc. have an economic moat?
Taysha Gene Therapies, Inc. (TSHA) has a Quality factor score of 26/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Taysha Gene Therapies, Inc. a buy, hold, or sell?
MoatMap’s current signal for Taysha Gene Therapies, Inc. (TSHA) is Strong Sell, based on a StockRank of 8/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Taysha Gene Therapies, Inc. in?
Taysha Gene Therapies, Inc. (TSHA) operates in the Healthcare sector, specifically the Biotechnology industry (United States).