AMLX

SellHot Air

Amylyx Pharmaceuticals, Inc. · Healthcare · United States · $3.4B cap · $37.7M/day traded

$27.09 -0.4% · close 26 Oct · scored 27 Oct

Hot Air: Rising on momentum alone: weak business, rich price.

30
StockRank
Get score and insider alerts
Quality
26
Value
23
Momentum
68

As of 27 Oct 2026, MoatMap's StockRank for Amylyx Pharmaceuticals, Inc. (AMLX) is 30/100, ranked against 24,000+ stocks in 35 markets (Quality 26, Value 23, Momentum 68, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-74.7%
peers -30.1%
D/E
0.0x
peers 0.2x
Dividend %
—
trailing yield

ABOUT AMYLYX PHARMACEUTICALS, INC.

Read

Amylyx Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company dedicated to developing and commercializing novel treatments for neurodegenerative diseases, most notably Amyotrophic Lateral Sclerosis (ALS). The company's competitive moat is derived from its innovative drug candidates addressing high unmet medical needs and the regulatory approvals achieved for its key product in major markets. It focuses on improving the lives of patients with devastating neurological conditions.

FINANCIAL SUMMARY (USD)

Year20212022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue—22.2M380.8M87.4M098.3%——28.3M-31.3%
EPS-1.59-3.390.73-4.43-1.53—-1.41-1.48-1.09—
Shares—66.5M67.7M68.6M109.9M+65.2%125.5M———
Debt—6.3M4.2M2.0M6.0M-1.7%5.3M———
Equity—340.6M433.4M164.8M305.3M-3.6%————
Op CF—-179.9M11.9M-167.6M-123.3M—-126.6M———
Inv CF—-239.0M92.1M75.7M14.0M—————
Fin CF—431.8M3.5M0.3M257.0M—————
Loading 1Y...
PRICE (1Y) · USD-18.3%
26.328.230.132.033.915 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkNo clear trendExperimental

No clear trend: not near its 52-week low, and not in a steady uptrend.

SwingsVery bumpy

Swung more than 91% of stocks we rank over the past year (86% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$27.09
RSI (14)
45.2
52-Week Range-34.2% from high
Low $10.83High $41.14

SCORE BREAKDOWN

Quality
26
ROIC
-52.3%14.8
ROE
-74.7%12.8
GP/Assets
-27.8%3.2
Op. Margin
0.0%38.6
FCF/Assets
-37.1%12.0
Piotroski
321.4
Int. Cover
—N/A
D/E Ratio
0.02x79.2
Current Ratio
12.12x90.1
Value
23
P/E (TTM)
—N/A
EV/EBITDA
-17.2x25.0
P/FCF
—N/A
P/B
12.7x8.1
P/S
—N/A
Div Yield
—N/A
Momentum
68
52W High %
66%49.0
RS 6M
54%92.6
SMA 50/200
1.58x98.6
EPS Rev 4W
+5.6%94.7
EPS Rev 12W
+13.9%87.8
EPS Improve
+23%35.4
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$3.4B
P/E (Forward)
-24.9x
Gross Margin
—

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of AMLX are excluded.

TickerCompanyMkt CapStockRankSignal
AMLXAmylyx Pharmaceuticals, Inc.(you)$3.4B30Sell
SUPNSupernus Pharmaceuticals, Inc.$2.4B35Hold
CURA.TOCuraleaf Holdings, Inc.$2.1B33Sell
HIMSHims & Hers Health, Inc.$6.5B26Sell
LQDALiquidia Corporation$3.8B46Hold
HROWHarrow, Inc.$1.5B17Strong Sell
XERSXeris Biopharma Holdings, Inc.$1.9B55Hold
VREO.CNVireo Growth Inc.$427M30Sell
ETONEton Pharmaceuticals, Inc.$1.4B59Hold
PBHPrestige Consumer Healthcare Inc.$2.3B68Buy

Peer medians: ROE -30.1% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

Request Deep Dive(50 Feathers)

Amylyx Pharmaceuticals, Inc. (AMLX): Stock Score Summary

Amylyx Pharmaceuticals, Inc. (AMLX) has a MoatMap StockRank of 30/100 based on Quality (26/100), Value (23/100), and Momentum (68/100) factor scores. The current signal is SELL.

Amylyx Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company dedicated to developing and commercializing novel treatments for neurodegenerative diseases, most notably Amyotrophic Lateral Sclerosis (ALS). The company's competitive moat is derived from its innovative drug candidates addressing high unmet medical needs and the regulatory approvals achieved for its key product in major markets. It focuses on improving the lives of patients with devastating neurological conditions.

Key Financial Metrics

Price$27.09
Market Cap$3.4B
P/E (Forward)-24.94
Price/Book12.66
Return on Equity-74.7%
Return on Invested Capital-52.3%
Debt/Equity0.02x
Operating Margin0.0%
Free Cash Flow$-123M

Amylyx Pharmaceuticals, Inc. operates in the Drug Manufacturers - Specialty & Generic industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Amylyx Pharmaceuticals, Inc.’s (AMLX) StockRank?
MoatMap’s StockRank for Amylyx Pharmaceuticals, Inc. (AMLX) is 30/100, with a Sell signal. It is a composite of Quality (26), Value (23), and Momentum (68), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Amylyx Pharmaceuticals, Inc. have an economic moat?
Amylyx Pharmaceuticals, Inc. (AMLX) has a Quality factor score of 26/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Amylyx Pharmaceuticals, Inc. a buy, hold, or sell?
MoatMap’s current signal for Amylyx Pharmaceuticals, Inc. (AMLX) is Sell, based on a StockRank of 30/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Amylyx Pharmaceuticals, Inc. in?
Amylyx Pharmaceuticals, Inc. (AMLX) operates in the Healthcare sector, specifically the Drug Manufacturers - Specialty & Generic industry (United States).