PYXS

Strong SellSinker

Pyxis Oncology, Inc. · Healthcare · United States · $201M cap · $1.9M/day traded

$1.69 +0.6% · close 26 Oct · scored 27 Oct

StockRank up 2.5 since 24 Oct: Momentum up 5.

Sinker: Weak, expensive and falling. Nothing here to keep it afloat.

9
StockRank
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Quality
12
Value
22
Momentum
48

As of 27 Oct 2026, MoatMap's StockRank for Pyxis Oncology, Inc. (PYXS) is 9/100, ranked against 24,000+ stocks in 35 markets (Quality 12, Value 22, Momentum 48, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-179.1%
peers -30.1%
D/E
1.6x
peers 0.2x
Dividend %
—
trailing yield

ABOUT PYXIS ONCOLOGY, INC.

Read

Pyxis Oncology, Inc., a clinical stage company, engages in the development of therapeutics to treat solid tumors.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue0016.1M13.9M-14.2%11.0M19.4K2.8M-55.2%
EPS-3.65-1.85-1.32-1.28—-1.40-1.21-1.11—
Shares35.0M44.8M60.0M62.7M+79.3%————
Debt18.9M21.3M20.2M18.7M-0.4%17.8M———
Equity160.8M125.7M120.8M53.4M-30.8%————
Op CF-89.3M-70.7M-57.7M-63.5M—-67.9M———
Inv CF-6.4M-104.8M8.2M58.9M—————
Fin CF0.2M5.9M59.3M0.6M—————
Loading 1Y...
PRICE (1Y) · USD-49.2%
1.72.12.53.03.415 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkFinding a floorExperimental

No new 52-week low for 41 weeks, 64% above that low, but not back above a rising 50-day average.

SwingsVery bumpy

Swung more than 98% of stocks we rank over the past year (125% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$1.69
RSI (14)
28.6
52-Week Range-69.5% from high
Low $1.03High $5.55

SCORE BREAKDOWN

Quality
12
ROIC
-122.0%5.1
ROE
-179.1%4.8
GP/Assets
9.5%24.8
Op. Margin
-812.7%7.7
FCF/Assets
-69.4%4.6
Piotroski
25.8
Int. Cover
—N/A
D/E Ratio
1.56x8.0
Current Ratio
1.34x21.2
Value
22
P/E (TTM)
—N/A
EV/EBITDA
-1.5x25.0
P/FCF
—N/A
P/B
9.3x11.5
P/S
18.2x15.2
Div Yield
—N/A
Momentum
48
52W High %
30%10.4
RS 6M
-11%49.7
SMA 50/200
1.28x92.6
EPS Rev 4W
+1.8%88.8
EPS Rev 12W
+8.1%82.4
EPS Improve
+21%34.2
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$201M
P/E (Forward)
-1.5x
Gross Margin
78.4%

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of PYXS are excluded.

TickerCompanyMkt CapStockRankSignal
PYXSPyxis Oncology, Inc.(you)$201M9Strong Sell
ALECAlector, Inc.$204M10Strong Sell
CAMPCAMP4 THERAPEUTICS CORPORATION$207M7Strong Sell
ZNTLZentalis Pharmaceuticals, Inc.$217M10Strong Sell
RNACCartesian Therapeutics, Inc.$187M10Strong Sell
ELDNEledon Pharmaceuticals, Inc.$187M11Strong Sell
LXEOLexeo Therapeutics, Inc.$230M10Strong Sell
TRDAEntrada Therapeutics, Inc.$172M7Strong Sell
LRMRLarimar Therapeutics, Inc.$244M10Strong Sell
IVVDInvivyd, Inc.$181M12Strong Sell

Peer medians: ROE -30.1% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

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Pyxis Oncology, Inc. (PYXS): Stock Score Summary

Pyxis Oncology, Inc. (PYXS) has a MoatMap StockRank of 9/100 based on Quality (12/100), Value (22/100), and Momentum (48/100) factor scores. The current signal is STRONG SELL.

Pyxis Oncology, Inc., a clinical stage company, engages in the development of therapeutics to treat solid tumors.

Key Financial Metrics

Price$1.69
Market Cap$201M
P/E (Forward)-1.52
Price/Book9.33
Return on Equity-179.1%
Return on Invested Capital-122.0%
Debt/Equity1.56x
Gross Margin78.4%
Operating Margin-812.7%
Free Cash Flow$-64M

Pyxis Oncology, Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Pyxis Oncology, Inc.’s (PYXS) StockRank?
MoatMap’s StockRank for Pyxis Oncology, Inc. (PYXS) is 9/100, with a Strong Sell signal. It is a composite of Quality (12), Value (22), and Momentum (48), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Pyxis Oncology, Inc. have an economic moat?
Pyxis Oncology, Inc. (PYXS) has a Quality factor score of 12/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Pyxis Oncology, Inc. a buy, hold, or sell?
MoatMap’s current signal for Pyxis Oncology, Inc. (PYXS) is Strong Sell, based on a StockRank of 9/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Pyxis Oncology, Inc. in?
Pyxis Oncology, Inc. (PYXS) operates in the Healthcare sector, specifically the Biotechnology industry (United States).