ZYME

SellHot Air

Zymeworks Inc. · Healthcare · United States · $2.0B cap · $33.3M/day traded

$28.37 +0.5% · close 26 Oct · scored 27 Oct

StockRank down 6.3 since 24 Oct: Momentum down 10.

Hot Air: Rising on momentum alone: weak business, rich price.

23
StockRank
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Report expected 5 Nov: the next-year EPS estimate has risen 217.8% over the last 14 weeks.

Quality
25
Value
20
Momentum
62

As of 27 Oct 2026, MoatMap's StockRank for Zymeworks Inc. (ZYME) is 23/100, ranked against 24,000+ stocks in 35 markets (Quality 25, Value 20, Momentum 62, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-72.3%
peers -30.1%
D/E
0.2x
peers 0.2x
Dividend %
—
trailing yield

ABOUT ZYMEWORKS INC.

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Zymeworks Inc. is a clinical-stage biopharmaceutical company dedicated to the development of next-generation, multifunctional biotherapeutics, with a primary focus on antibody-drug conjugates (ADCs) and multispecific antibodies for oncology. The company's competitive moat is established by its proprietary therapeutic platforms, including Azymetric and EFECT, which have been validated through lucrative licensing agreements with global pharmaceutical giants. These strategic collaborations provide Zymeworks with substantial non-dilutive funding while accelerating the clinical development of its diverse oncology pipeline.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue412.5M76.0M76.3M106.0M-36.4%37.1M293.5M371.4M87.2%
EPS1.91-1.72-1.62-1.08—-2.02———
Shares63.1M70.1M69.0M75.2M+19.2%71.2M———
Debt28.1M26.7M18.5M18.3M-13.4%16.0M———
Equity493.0M464.8M338.8M268.5M-18.3%————
Op CF144.1M-118.3M-110.1M-33.0M—-119.3M———
Inv CF-53.8M-207.3M38.8M26.7M—————
Fin CF108.6M81.9M-20.4M-18.6M—————
Loading 1Y...
PRICE (1Y) · USD+8.9%
24.825.726.627.528.415 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkIn an uptrendExperimental

Above its 200-day average and 9% below its 52-week high.

SwingsBumpy

Swung more than 69% of stocks we rank over the past year (55% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$28.37
RSI (14)
64.8
52-Week Range-9.5% from high
Low $16.00High $31.34

SCORE BREAKDOWN

Quality
25
ROIC
-49.0%16.1
ROE
-72.3%13.3
GP/Assets
-26.4%3.4
Op. Margin
-919.0%7.2
FCF/Assets
-10.2%30.2
Piotroski
438.6
Int. Cover
—N/A
D/E Ratio
0.20x50.3
Current Ratio
6.32x78.4
Value
20
P/E (TTM)
—N/A
EV/EBITDA
-11.6x25.0
P/FCF
—N/A
P/B
25.1x3.5
P/S
54.5x8.4
Div Yield
—N/A
Momentum
62
52W High %
91%86.6
RS 6M
-7%54.4
SMA 50/200
1.08x74.7
EPS Rev 4W
-2.1%10.0
EPS Rev 12W
+217.8%99.7
EPS Improve
+145%82.2
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$2.0B
P/E (Forward)
31.3x
Gross Margin
—

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of ZYME are excluded.

TickerCompanyMkt CapStockRankSignal
ZYMEZymeworks Inc.(you)$2.0B23Sell
RXRXRecursion Pharmaceuticals, Inc.$2.0B22Sell
BHVNBiohaven Ltd.$2.1B25Sell
XNCRXencor, Inc.$1.9B26Sell
PGENPrecigen, Inc.$2.2B26Sell
NUVBNuvation Bio Inc.$1.6B23Sell
TRVITrevi Therapeutics, Inc.$1.8B20Strong Sell
BRVEBraveheart Bio, Inc.$1.9B17Strong Sell
ABSIAbsci Corporation$1.6B21Sell
AGIOAgios Pharmaceuticals, Inc.$2.2B29Sell

Peer medians: ROE -30.1% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

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Zymeworks Inc. (ZYME): Stock Score Summary

Zymeworks Inc. (ZYME) has a MoatMap StockRank of 23/100 based on Quality (25/100), Value (20/100), and Momentum (62/100) factor scores. The current signal is SELL.

Zymeworks Inc. is a clinical-stage biopharmaceutical company dedicated to the development of next-generation, multifunctional biotherapeutics, with a primary focus on antibody-drug conjugates (ADCs) and multispecific antibodies for oncology. The company's competitive moat is established by its proprietary therapeutic platforms, including Azymetric and EFECT, which have been validated through lucrative licensing agreements with global pharmaceutical giants. These strategic collaborations provide Zymeworks with substantial non-dilutive funding while accelerating the clinical development of its diverse oncology pipeline.

Key Financial Metrics

Price$28.37
Market Cap$2.0B
P/E (Forward)31.26
Price/Book25.08
Return on Equity-72.3%
Return on Invested Capital-49.0%
Debt/Equity0.20x
Operating Margin-919.0%
Revenue Growth-90.6%
Free Cash Flow$-35M

Zymeworks Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Zymeworks Inc.’s (ZYME) StockRank?
MoatMap’s StockRank for Zymeworks Inc. (ZYME) is 23/100, with a Sell signal. It is a composite of Quality (25), Value (20), and Momentum (62), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Zymeworks Inc. have an economic moat?
Zymeworks Inc. (ZYME) has a Quality factor score of 25/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Zymeworks Inc. a buy, hold, or sell?
MoatMap’s current signal for Zymeworks Inc. (ZYME) is Sell, based on a StockRank of 23/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Zymeworks Inc. in?
Zymeworks Inc. (ZYME) operates in the Healthcare sector, specifically the Biotechnology industry (United States).