AXSM

Strong SellSinker

Axsome Therapeutics, Inc. · Healthcare · United States · $7.6B cap · $123.1M/day traded

$144.06 -0.7% · close 26 Oct · scored 27 Oct

Sinker: Weak, expensive and falling. Nothing here to keep it afloat.

13
StockRank
Get score and insider alerts

Report expected 2 Nov: the next-year EPS estimate has fallen 38.1% over the last 14 weeks.

Quality
34
Value
21
Momentum
33

As of 27 Oct 2026, MoatMap's StockRank for Axsome Therapeutics, Inc. (AXSM) is 13/100, ranked against 24,000+ stocks in 35 markets (Quality 34, Value 21, Momentum 33, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-245.1%
peers -30.1%
D/E
2.7x
peers 0.2x
Dividend %
—
trailing yield

ABOUT AXSOME THERAPEUTICS, INC.

Read

Axsome Therapeutics, Inc. is a biopharmaceutical company focused on developing novel therapies for central nervous system (CNS) disorders, with a pipeline addressing areas like depression, migraine, and narcolepsy. The company's competitive advantage stems from its innovative product candidates and proprietary technology designed to enhance drug efficacy and safety. Axsome seeks to address significant unmet medical needs in large and growing CNS markets, holding multiple FDA-approved products.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue50.0M270.6M385.7M638.5M133.7%776.6M951.9M1.5B54.1%
EPS-4.60-5.27-5.99-3.68—-3.74-2.983.69—
Shares43.5M47.4M48.7M50.9M+17.0%52.4M———
Debt94.7M186.4M193.0M218.1M32.1%224.7M———
Equity109.6M191.0M57.0M88.3M-6.9%————
Op CF-116.5M-145.1M-128.4M-93.4M—-71.3M———
Inv CF-53.7M-0.6M-0.3M-0.5M—————
Fin CF284.6M331.0M57.8M101.5M—————
Loading 1Y...
PRICE (1Y) · USD-29.4%
14416217919721415 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkNo clear trendExperimental

No clear trend: not near its 52-week low, and not in a steady uptrend.

SwingsBumpy

Swung more than 54% of stocks we rank over the past year (44% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$144.06
RSI (14)
19.5
52-Week Range-44.6% from high
Low $123.50High $260.19

SCORE BREAKDOWN

Quality
34
ROIC
-59.8%12.9
ROE
-245.1%3.1
GP/Assets
105.0%98.6
Op. Margin
-23.4%23.9
FCF/Assets
-10.4%29.7
Piotroski
549.3
Int. Cover
-37.1x13.6
D/E Ratio
2.70x3.9
Current Ratio
1.43x24.1
Value
21
P/E (TTM)
—N/A
EV/EBITDA
-43.4x25.0
P/FCF
—N/A
P/B
91.0x0.7
P/S
9.8x24.0
Div Yield
—N/A
Momentum
33
52W High %
55%33.5
RS 6M
-30%26.6
SMA 50/200
0.95x45.3
EPS Rev 4W
-26.6%1.5
EPS Rev 12W
-38.1%2.8
EPS Improve
+199%87.5
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$7.6B
P/E (Forward)
39.3x
Gross Margin
93.2%

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of AXSM are excluded.

TickerCompanyMkt CapStockRankSignal
AXSMAxsome Therapeutics, Inc.(you)$7.6B13Strong Sell
ARWRArrowhead Pharmaceuticals, Inc.$8.2B14Strong Sell
PRAXPraxis Precision Medicines, Inc.$7.1B16Strong Sell
CYTKCytokinetics, Incorporated$8.5B17Strong Sell
ERASErasca, Inc.$5.0B13Strong Sell
IMVTImmunovant, Inc.$5.9B16Strong Sell
IONSIonis Pharmaceuticals, Inc.$7.1B4Strong Sell
CGONCG Oncology, Inc.$5.5B16Strong Sell
COGTCogent Biosciences, Inc.$5.4B9Strong Sell
SRRKScholar Rock Holding Corporation$5.1B10Strong Sell

Peer medians: ROE -30.1% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

Request Deep Dive(50 Feathers)

Axsome Therapeutics, Inc. (AXSM): Stock Score Summary

Axsome Therapeutics, Inc. (AXSM) has a MoatMap StockRank of 13/100 based on Quality (34/100), Value (21/100), and Momentum (33/100) factor scores. The current signal is STRONG SELL.

Axsome Therapeutics, Inc. is a biopharmaceutical company focused on developing novel therapies for central nervous system (CNS) disorders, with a pipeline addressing areas like depression, migraine, and narcolepsy. The company's competitive advantage stems from its innovative product candidates and proprietary technology designed to enhance drug efficacy and safety. Axsome seeks to address significant unmet medical needs in large and growing CNS markets, holding multiple FDA-approved products.

Key Financial Metrics

Price$144.06
Market Cap$7.6B
P/E (Forward)39.27
Price/Book91.05
Return on Equity-245.1%
Return on Invested Capital-59.8%
Debt/Equity2.70x
Gross Margin93.2%
Operating Margin-23.4%
Revenue Growth45.5%
Free Cash Flow$-72M

Axsome Therapeutics, Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Axsome Therapeutics, Inc.’s (AXSM) StockRank?
MoatMap’s StockRank for Axsome Therapeutics, Inc. (AXSM) is 13/100, with a Strong Sell signal. It is a composite of Quality (34), Value (21), and Momentum (33), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Axsome Therapeutics, Inc. have an economic moat?
Axsome Therapeutics, Inc. (AXSM) has a Quality factor score of 34/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Axsome Therapeutics, Inc. a buy, hold, or sell?
MoatMap’s current signal for Axsome Therapeutics, Inc. (AXSM) is Strong Sell, based on a StockRank of 13/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Axsome Therapeutics, Inc. in?
Axsome Therapeutics, Inc. (AXSM) operates in the Healthcare sector, specifically the Biotechnology industry (United States).