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IONS

STRONG SELL

Ionis Pharmaceuticals, Inc. · Healthcare · United States · $9.3B · Avg Vol: $213M/d

7
StockRank
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Q
23
V
23
M
32
P/E (TTM)
ROE
-67.6%
D/E
5.3x
Dividend %

COMPANY DESCRIPTION

Ionis Pharmaceuticals, Inc. is a leading biotechnology company pioneering RNA-targeted therapeutics, developing a broad pipeline of innovative medicines for severe and rare diseases using its proprietary antisense technology platform. The company possesses a unique and validated antisense technology platform with multiple approved drugs and a robust pipeline, providing a significant competitive advantage through its deep intellectual property portfolio. Ionis is a pioneer and leader in antisense oligonucleotide (ASO) drug discovery, offering a differentiated approach to treating a wide range of genetic and severe diseases.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue587.4M787.6M705.1M943.7M17.1%1.1B889.9M1.4B21.5%
EPS-1.90-2.56-3.04-2.38-2.01-2.62-1.07
Shares142.1M144.3M157.9M163.3M+15.0%165.3M
Debt1.4B1.5B1.4B2.1B14.7%2.6B
Equity572.9M386.7M588.4M489.1M-5.1%
Op CF-274.4M-307.5M-500.9M-268.6M-910.6M
Inv CF-262.6M-214.1M-134.0M-277.8M
Fin CF-55.3M644.1M478.1M675.8M
Loading 1Y...
PRICE (1Y)-23.4%
52.9561.3069.6477.9986.33Jun 11Jul 6Jul 24
SMA 50SMA 200
Close
$56.55
RSI (14)
16.8
52W High
$86.74
From 52W High
0.7%

SCORE BREAKDOWN

Quality
23
ROIC
-10.8%35.3
ROE
-67.6%14.2
GP/Assets
3.3%17.1
Op. Margin
-47.7%21.8
FCF/Assets
-22.9%15.8
Piotroski
430.1
Int. Cover
-3.5x30.2
D/E Ratio
5.31x2.2
Current Ratio
4.10x64.9
Value
23
P/E (TTM)
N/A
EV/EBITDA
-27.7x25.0
P/FCF
N/A
P/B
17.9x6.2
P/S
8.3x30.7
Div Yield
N/A
Momentum
32
52W High %
65%46.9
RS 6M
-39%25.9
SMA 50/200
0.95x52.8
EPS Rev 4W
-53.5%0.5
EPS Rev 12W
-84.4%0.2
EPS Improve
+43%51.3
Q Growth
N/A

FUNDAMENTALS

Market Cap
$9.3B
P/E (Forward)
-46.4x
Gross Margin
10.9%

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of IONS are excluded.

TickerCompanyMkt CapStockRankSignal
IONSIonis Pharmaceuticals, Inc.(you)$9.3B7STRONG SELL
SMMTSummit Therapeutics Inc.$10.9B9STRONG SELL
MANEVeradermics, Incorporated$4.6B8STRONG SELL
SRRKScholar Rock Holding Corporation$5.7B13STRONG SELL
0JAV.LInsmed Incorporated$18.9B10STRONG SELL
KYMRKymera Therapeutics, Inc.$9.1B25SELL
PBLSParabilis Medicines, Inc.$3.8B5STRONG SELL
CYTKCytokinetics, Incorporated$11.0B26SELL
PCVXVaxcyte, Inc.$7.9B27SELL
PRAXPraxis Precision Medicines, Inc.$9.1B29SELL

Peer medians: ROE -25.5% · P/E 27.7x · Gross margin 50.7%

Ionis Pharmaceuticals, Inc. (IONS) — Stock Score Summary

Ionis Pharmaceuticals, Inc. (IONS) has a MoatMap StockRank of 7/100 based on Quality (23/100), Value (23/100), and Momentum (32/100) factor scores. The current signal is STRONG SELL.

Ionis Pharmaceuticals, Inc. is a leading biotechnology company pioneering RNA-targeted therapeutics, developing a broad pipeline of innovative medicines for severe and rare diseases using its proprietary antisense technology platform. The company possesses a unique and validated antisense technology platform with multiple approved drugs and a robust pipeline, providing a significant competitive advantage through its deep intellectual property portfolio. Ionis is a pioneer and leader in antisense oligonucleotide (ASO) drug discovery, offering a differentiated approach to treating a wide range of genetic and severe diseases.

Key Financial Metrics

Price$56.55
Market Cap$9.3B
P/E (Forward)-46.39
Price/Book17.88
Return on Equity-67.6%
Return on Invested Capital-10.8%
Debt/Equity5.31x
Gross Margin10.9%
Operating Margin-47.7%
Revenue Growth87.0%
Free Cash Flow$-808M

Ionis Pharmaceuticals, Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Ionis Pharmaceuticals, Inc.’s (IONS) StockRank?
MoatMap’s StockRank for Ionis Pharmaceuticals, Inc. (IONS) is 7/100, with a Strong Sell signal. It is a composite of Quality (23), Value (23), and Momentum (32) factor ranks across MoatMap’s 20,000+ stock universe.
Does Ionis Pharmaceuticals, Inc. have an economic moat?
Ionis Pharmaceuticals, Inc. (IONS) has a Quality factor score of 23/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage — the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Ionis Pharmaceuticals, Inc. a buy, hold, or sell?
MoatMap’s current signal for Ionis Pharmaceuticals, Inc. (IONS) is Strong Sell, based on a StockRank of 7/100. Signals are derived mechanically from the StockRank composite and should be one input among many — combine with your own thesis on management, competitive position, and valuation.
What sector is Ionis Pharmaceuticals, Inc. in?
Ionis Pharmaceuticals, Inc. (IONS) operates in the Healthcare sector, specifically the Biotechnology industry (United States).