PRAX

Strong SellSinker

Praxis Precision Medicines, Inc. · Healthcare · United States · $7.1B cap · $147.5M/day traded

$267.39 +5.7% · close 26 Oct · scored 27 Oct

StockRank up 2.0 since 24 Oct: Momentum up 3 after a 6% price rise.

Sinker: Weak, expensive and falling. Nothing here to keep it afloat.

16
StockRank
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Quality
30
Value
25
Momentum
39

As of 27 Oct 2026, MoatMap's StockRank for Praxis Precision Medicines, Inc. (PRAX) is 16/100, ranked against 24,000+ stocks in 35 markets (Quality 30, Value 25, Momentum 39, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-38.9%
peers -30.1%
D/E
0.0x
peers 0.2x
Dividend %
—
trailing yield

ABOUT PRAXIS PRECISION MEDICINES, INC.

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Praxis Precision Medicines, Inc. is a clinical-stage biotechnology company dedicated to developing novel therapies for central nervous system (CNS) disorders. Its drug pipeline targets conditions such as epilepsy, movement disorders, and depression by addressing neuronal excitation-inhibition imbalance. The company distinguishes itself through a precision medicine approach, aiming to provide targeted treatments for patients with high unmet medical needs.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue02.4M8.6M0249.5%—0.8M345.1M243.0%
EPS-8.22-5.89-10.21-13.48—-12.95-14.02-9.50—
Shares27.9M27.9M19.4M25.2M-9.6%27.9M———
Debt3.5M2.5M1.4M0.1M-68.4%1.1M———
Equity76.1M69.7M445.4M878.1M126.0%————
Op CF-185.0M-111.1M-131.8M-249.1M—-305.1M———
Inv CF96.9M39.0M-248.5M-311.1M—————
Fin CF10.5M91.9M514.3M702.2M—————
Loading 1Y...
PRICE (1Y) · USD-14.5%
23925727629431315 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkNo clear trendExperimental

No clear trend: not near its 52-week low, and not in a steady uptrend.

SwingsVery bumpy

Swung more than 85% of stocks we rank over the past year (73% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$267.39
RSI (14)
44.2
52-Week Range-31.9% from high
Low $154.45High $392.70

SCORE BREAKDOWN

Quality
30
ROIC
-43.1%18.3
ROE
-38.9%21.7
GP/Assets
-31.0%2.6
Op. Margin
0.0%38.6
FCF/Assets
-26.6%17.4
Piotroski
321.4
Int. Cover
—N/A
D/E Ratio
0.00x94.3
Current Ratio
15.73x93.4
Value
25
P/E (TTM)
—N/A
EV/EBITDA
-16.7x25.0
P/FCF
—N/A
P/B
5.3x23.2
P/S
—N/A
Div Yield
—N/A
Momentum
39
52W High %
68%52.7
RS 6M
-26%31.1
SMA 50/200
0.98x52.6
EPS Rev 4W
-2.2%9.5
EPS Rev 12W
+1.6%69.2
EPS Improve
+27%38.2
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$7.1B
P/E (Forward)
-26.6x
Gross Margin
—

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of PRAX are excluded.

TickerCompanyMkt CapStockRankSignal
PRAXPraxis Precision Medicines, Inc.(you)$7.1B16Strong Sell
IMVTImmunovant, Inc.$5.9B16Strong Sell
ARWRArrowhead Pharmaceuticals, Inc.$8.2B14Strong Sell
AXSMAxsome Therapeutics, Inc.$7.6B13Strong Sell
CGONCG Oncology, Inc.$5.5B16Strong Sell
CYTKCytokinetics, Incorporated$8.5B17Strong Sell
ERASErasca, Inc.$5.0B13Strong Sell
KYMRKymera Therapeutics, Inc.$9.1B22Sell
COGTCogent Biosciences, Inc.$5.4B9Strong Sell
IONSIonis Pharmaceuticals, Inc.$7.1B4Strong Sell

Peer medians: ROE -30.1% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

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Praxis Precision Medicines, Inc. (PRAX): Stock Score Summary

Praxis Precision Medicines, Inc. (PRAX) has a MoatMap StockRank of 16/100 based on Quality (30/100), Value (25/100), and Momentum (39/100) factor scores. The current signal is STRONG SELL.

Praxis Precision Medicines, Inc. is a clinical-stage biotechnology company dedicated to developing novel therapies for central nervous system (CNS) disorders. Its drug pipeline targets conditions such as epilepsy, movement disorders, and depression by addressing neuronal excitation-inhibition imbalance. The company distinguishes itself through a precision medicine approach, aiming to provide targeted treatments for patients with high unmet medical needs.

Key Financial Metrics

Price$267.39
Market Cap$7.1B
P/E (Forward)-26.62
Price/Book5.27
Return on Equity-38.9%
Return on Invested Capital-43.1%
Debt/Equity0.00x
Operating Margin0.0%
Free Cash Flow$-249M

Praxis Precision Medicines, Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Praxis Precision Medicines, Inc.’s (PRAX) StockRank?
MoatMap’s StockRank for Praxis Precision Medicines, Inc. (PRAX) is 16/100, with a Strong Sell signal. It is a composite of Quality (30), Value (25), and Momentum (39), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Praxis Precision Medicines, Inc. have an economic moat?
Praxis Precision Medicines, Inc. (PRAX) has a Quality factor score of 30/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Praxis Precision Medicines, Inc. a buy, hold, or sell?
MoatMap’s current signal for Praxis Precision Medicines, Inc. (PRAX) is Strong Sell, based on a StockRank of 16/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Praxis Precision Medicines, Inc. in?
Praxis Precision Medicines, Inc. (PRAX) operates in the Healthcare sector, specifically the Biotechnology industry (United States).