TYRA

Strong SellSinker

Tyra Biosciences, Inc. · Healthcare · United States · $1.4B cap · $17.0M/day traded

$20.42 -0.1% · close 26 Oct · scored 27 Oct

Sinker: Weak, expensive and falling. Nothing here to keep it afloat.

12
StockRank
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Quality
29
Value
27
Momentum
32

As of 27 Oct 2026, MoatMap's StockRank for Tyra Biosciences, Inc. (TYRA) is 12/100, ranked against 24,000+ stocks in 35 markets (Quality 29, Value 27, Momentum 32, each scored against its sector).

Does StockRank work? Each month we publish how every decile did, whichever way it went. See the record →

P/E (TTM)
—
peers 27.2x
ROE
-45.3%
peers -30.1%
D/E
0.0x
peers 0.2x
Dividend %
—
trailing yield

ABOUT TYRA BIOSCIENCES, INC.

Read

Tyra Biosciences, Inc. is a clinical-stage biotechnology company focused on developing precision medicines for patients with a variety of cancers, particularly those with acquired resistance to existing therapies. The company's competitive moat is underpinned by its proprietary SNF platform, enabling the discovery of highly selective small molecule inhibitors targeting resistance mutations in oncology. Tyra Biosciences is positioned as an innovator in addressing the challenge of drug resistance in cancer treatment.

FINANCIAL SUMMARY (USD)

Year2022202320242025CAGRTTM2026E2027EFwd CAGR
Revenue0000———3.1M—
EPS-1.32-1.62-1.51-2.01—-2.39-2.64-2.77—
Shares42.4M43.0M50.7M53.7M+26.8%68.8M———
Debt2.6M6.5M6.2M5.8M30.4%5.6M———
Equity257.8M204.3M343.2M259.2M0.2%————
Op CF-50.3M-50.1M-69.8M-95.1M—-109.7M———
Inv CF-0.6M-144.6M-98.4M72.5M—————
Fin CF0.6M1.5M202.1M8.1M—————
Loading 1Y...
PRICE (1Y) · USD-19.7%
18.520.322.123.925.715 Sep6 Oct26 Oct
SMA 50SMA 200

Price checkNo clear trendExperimental

No clear trend: not near its 52-week low, and not in a steady uptrend.

SwingsVery bumpy

Swung more than 81% of stocks we rank over the past year (67% a year).

How this is worked out

StockRank judges the business. The price check reads only the chart: it is the price side of the Momentum score, in words.

The rules: Still falling is a new 52-week low in the last two weeks, at least 25% below the high. Finding a floor is no new low since. Turning up is 20 or more trading days without a new low, at least 10% off it, and back above a rising 50-day average. In an uptrend is above the 200-day average and within 15% of the high.

In 2,112 US drawdowns since 2001, buying while the price was still falling was followed by a further 20% drop 42% of the time. Waiting for a turn like this one cut that to 33%, at about 7% higher prices and with no better returns. Part of that cut is simply not buying: 13% of falls never turned, and waiting kept those out. Among turns that were bought, 38% still fell another 20%, and 33% of turns were followed by a new low within six months. The benefit was largest in crashes such as 2008 and 2020.

What it measures: day-to-day price moves over the past year, as a yearly figure, ranked against every stock we cover. Very calm under 20% a year, Calm 20 to 30%, Average 30 to 40%, Bumpy 40 to 55%, Very bumpy above that.

What we found: across about 13,500 stocks in 34 markets (2002 to 2025), past swings were a good guide to the next year's, and bumpier stocks fell further. How much further changed too much between eras to put a number on it.

Calm is not safe: a calm stock can still slide steadily.

Rules fixed before any data was fetched. Describes the chart, not a recommendation.

Close
$20.42
RSI (14)
51.6
52-Week Range-49.8% from high
Low $13.35High $40.65

SCORE BREAKDOWN

Quality
29
ROIC
-60.7%12.5
ROE
-45.3%19.7
GP/Assets
—N/A
Op. Margin
0.0%38.6
FCF/Assets
-38.9%11.1
Piotroski
12.3
Int. Cover
—N/A
D/E Ratio
0.02x82.0
Current Ratio
14.90x92.8
Value
27
P/E (TTM)
—N/A
EV/EBITDA
-5.5x25.0
P/FCF
—N/A
P/B
3.4x37.1
P/S
—N/A
Div Yield
—N/A
Momentum
32
52W High %
50%27.6
RS 6M
-51%10.4
SMA 50/200
0.77x12.4
EPS Rev 4W
+3.6%93.1
EPS Rev 12W
+1.7%69.9
EPS Improve
-16%15.4
Q Growth
—N/A

FUNDAMENTALS

Market Cap
$1.4B
P/E (Forward)
-7.4x
Gross Margin
—

SECTOR PEERS

Closest peers in Healthcare, ranked by industry match, size, and score similarity. Cross-listings of TYRA are excluded.

TickerCompanyMkt CapStockRankSignal
TYRATyra Biosciences, Inc.(you)$1.4B12Strong Sell
DMRADamora Therapeutics, Inc.$1.3B12Strong Sell
RAPPRapport Therapeutics, Inc.$1.2B12Strong Sell
NTLAIntellia Therapeutics, Inc.$1.6B11Strong Sell
RAREUltragenyx Pharmaceutical Inc.$1.5B11Strong Sell
GPCRStructure Therapeutics Inc.$1.5B15Strong Sell
ORICORIC Pharmaceuticals, Inc.$1.4B16Strong Sell
KARDKardigan, Inc.$1.2B14Strong Sell
LYCALycia Therapeutics, Inc.$1.6B10Strong Sell
MAZEMaze Therapeutics, Inc.$1.7B13Strong Sell

Peer medians: ROE -30.1% · P/E 27.2x · Gross margin 63.3%

Company Deep Dive

Business segments breakdown, earnings transcript analysis, management credibility scoring, competitive landscape, and scenario modelling.

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Tyra Biosciences, Inc. (TYRA): Stock Score Summary

Tyra Biosciences, Inc. (TYRA) has a MoatMap StockRank of 12/100 based on Quality (29/100), Value (27/100), and Momentum (32/100) factor scores. The current signal is STRONG SELL.

Tyra Biosciences, Inc. is a clinical-stage biotechnology company focused on developing precision medicines for patients with a variety of cancers, particularly those with acquired resistance to existing therapies. The company's competitive moat is underpinned by its proprietary SNF platform, enabling the discovery of highly selective small molecule inhibitors targeting resistance mutations in oncology. Tyra Biosciences is positioned as an innovator in addressing the challenge of drug resistance in cancer treatment.

Key Financial Metrics

Price$20.42
Market Cap$1.4B
P/E (Forward)-7.38
Price/Book3.45
Return on Equity-45.3%
Return on Invested Capital-60.7%
Debt/Equity0.02x
Operating Margin0.0%
Free Cash Flow$-110M

Tyra Biosciences, Inc. operates in the Biotechnology industry, part of the Healthcare sector (United States).

Frequently Asked Questions

What is Tyra Biosciences, Inc.’s (TYRA) StockRank?
MoatMap’s StockRank for Tyra Biosciences, Inc. (TYRA) is 12/100, with a Strong Sell signal. It is a composite of Quality (29), Value (27), and Momentum (32), each scored against its sector. The composite is then ranked across MoatMap’s universe of 24,000+ stocks.
Does Tyra Biosciences, Inc. have an economic moat?
Tyra Biosciences, Inc. (TYRA) has a Quality factor score of 29/100. The Quality factor combines ROIC, Piotroski F-Score, and leverage: the financial fingerprints of a durable competitive advantage. A Quality score above 70 typically indicates a company with the characteristics of a moated business.
Is Tyra Biosciences, Inc. a buy, hold, or sell?
MoatMap’s current signal for Tyra Biosciences, Inc. (TYRA) is Strong Sell, based on a StockRank of 12/100. Signals are derived mechanically from the StockRank composite and should be one input among many; combine with your own thesis on management, competitive position, and valuation.
What sector is Tyra Biosciences, Inc. in?
Tyra Biosciences, Inc. (TYRA) operates in the Healthcare sector, specifically the Biotechnology industry (United States).